What if the US restricts gene-synthesis and AI protein-design tools?
Restricting DNA-synthesis hardware and AI protein-design models fragments pharma/biotech R&D, not chips - the real names are Twist Bioscience, gene-synthesis vendors and AI-bio platforms, so mapping this to TSMC/Nvidia/ASML is a category error. No clean analogue; closest is the nascent BIS biotech/Tencent-Wuxi listing pressure. The 1-3yr horizon and biotech locus mean equity impact is diffuse; the forward angle is dual-use bio controls are new regulatory terrain, so the semiconductor_risk root is misapplied.
how we built this number — every step
The class rate is measured from our dated, sourced event library (decade-normalized Poisson — the full table is public at base_rates.json). The variant’s share within its class is the analyst’s editorial call, published so you can audit it. A wider range means thinner precedent. Full recipe: methodology · scored at Reality Check.
The butterfly cascade
How this trigger trickles across markets, left → right — the root shock, its first‑order moves, then the ripple effects. Drag any node; tap a market for its real price history.
Resolution timeline — how this probability is moving
Our model's odds (gold) over time vs the crowd's (Polymarket, blue), from the past toward the 1–3 years horizon. Each dot is a real macro event that nudged the probability — green pushed it up, red pushed it down. Tap a dot for the source. The gold path is an illustrative reconstruction anchored to today's estimate — real dated events, not a live re-estimate history.
What it would mean
If this plays out, it is a mixed shock. US restricts DNA-synthesis hardware and AI protein-design models, fragmenting global pharma R&D supply chains. The trigger decomposes into signed root‑shocks — Trade tension ▲ — which propagate through our causal graph to the markets below.
If it happens — the markets it would move
Biggest moves first. Projected moves are cascade-model priors; hist A–B% = what comparable past events actually did (measured abnormal returns), and model prior · unmeasured marks markets with no analogue backing yet. Tap any market for its price history.
| Market | Class | Projected move | |
|---|---|---|---|
| 1 | Nasdaq 100 NDXon Hyperliquid 📈 chart | Index | ▼ -1.2% hist -0.85–-0.3% · other way -0.29% (n=12) |
| 2 | Semiconductors SMHon Hyperliquid 📈 chart | Equity | ▼ -1.1% hist -0.79–+0.07% · other way +2.4% (n=12) |
| 3 | Nvidia NVDAon Hyperliquid 📈 chart | Equity | ▼ -0.9% hist -1.55–+1.83% · other way +4.34% (n=12) |
| 4 | TSMC TSMon Hyperliquid 📈 chart | Equity | ▼ -0.9% hist -1.06–+0.92% · other way +3.35% (n=12) |
| 5 | Alibaba BABAon Hyperliquid 📈 chart | Equity | ▼ -0.8% hist -0.83–+0.61% · other way -2.98% (n=12) |
| 6 | Tech sector XLK 📈 chart | Equity | ▼ -0.8% hist -0.56–-0.12% · other way -0.38% (n=12) |
| 7 | ASML ASMLon Hyperliquid 📈 chart | Equity | ▼ -0.7% hist -2.63–+0.86% · other way -0.64% (n=12) |
| 8 | AMD AMDon Hyperliquid 📈 chart | Equity | ▼ -0.7% hist -0.87–+0.7% · other way -1.13% (n=12) |
| 9 | Broadcom AVGOon Hyperliquid 📈 chart | Equity | ▼ -0.7% hist -1.04–+1.34% · other way +1.14% (n=12) |
| 10 | Micron MUon Hyperliquid 📈 chart | Equity | ▼ -0.7% hist -3.9–+0.8% · other way +5.45% (n=12) |
| 11 | Marvell MRVLon Hyperliquid 📈 chart | Equity | ▼ -0.7% hist -0.66–+0.44% · other way +1.84% (n=12) |
| 12 | Chinese yuan CNY 📈 chart | FX | ▼ -0.6% hist -0.66–-0.04% · other way -0.81% (n=12) |
| 13 | Qualcomm QCOMon Hyperliquid 📈 chart | Equity | ▼ -0.5% hist -3.79–+0.76% · other way -0.58% (n=12) |
| 14 | Intel INTCon Hyperliquid 📈 chart | Equity | ▼ -0.4% hist -8.53–+0.08% · other way -5.61% (n=12) |
Probable recommendation
Why we may diverge from history
Trust the cascade short on MSTR/SOL: +6%/+1% realized is crypto-bull regime contamination from 2024-25 windows, hit-rate 0.67 — gene-synthesis controls carry zero crypto channel, history is regime noise.
Historical precedent — what analogous events actually did
Across 40 analogous events (overlap‑weighted), as abnormal returns — market beta stripped, so it's the event's own effect, not the market backdrop. Shown at 20 days (persistent) and 5 days (immediate); ↺ fades = the two horizons disagree. Confidence = consistency × sample × significance.
| Asset | History says | Abnormal (20d · 5d) | Hit | n | Confidence | vs cascade |
|---|---|---|---|---|---|---|
| INTC INTC | SHORT | -6.3% · 5d -3.4% | 81% | 39 | 0.61 | ✓ matches cascade |
| ETH ETH | SHORT | -7.3% · 5d -6.1% | 71% | 38 | 0.33 | ✓ matches cascade |
| XCU XCU | SHORT | -1.4% · 5d -0.9% | 70% | 39 | 0.32 | ✓ matches cascade |
| GBPUSD GBPUSD | LONG | +0.4% · 5d -0.1% ↺ fades | 67% | 39 | 0.30 | ⚠ differs |
| KWEB KWEB | SHORT | -1.0% · 5d -0.5% | 65% | 39 | 0.27 | ✓ matches cascade |
| QCOM QCOM | SHORT | -3.1% · 5d -2.7% | 67% | 39 | 0.25 | ✓ matches cascade |
| MU MU | SHORT | -3.2% · 5d -2.9% | 65% | 39 | 0.23 | ✓ matches cascade |
| TRY TRY | SHORT | -1.8% · 5d +0.7% ↺ fades | 65% | 39 | 0.23 | ✓ matches cascade |
| Gold XAU | LONG | +1.3% · 5d +0.1% | 63% | 39 | 0.23 | · |
| EURUSD EURUSD | LONG | +0.4% · 5d +0.1% | 63% | 39 | 0.22 | ⚠ differs |
| SOL SOL | SHORT | -7.9% · 5d -8.4% | 64% | 37 | 0.21 | ✓ matches cascade |
| FCX FCX | SHORT | -1.6% · 5d -1.2% | 60% | 39 | 0.17 | ✓ matches cascade |
| CNY CNY | SHORT | -0.3% · 5d -0.2% | 58% | 39 | 0.16 | ✓ matches cascade |
| Bitcoin BTC | SHORT | -3.9% · 5d -3.3% | 60% | 39 | 0.16 | · |
Why this probability
Gene-synthesis/AI-bio controls emerging but novel and slow; 1-3yr window only modestly lifts odds. A base‑rate‑anchored prior, continuously scored against what actually happens — not a forecast.